Manchester Central will play host to Labour's 2012 and 2014 conferences, as the party confirmed that its annual event will remain in the north-west for the next five years.
These events add to the 2010 conference that has been previously awarded to the city and follows the success of the 2006 and 2008 events staged there.
"Manchester has firmly established itself as a world-class conference destination. The return of the Labour party conference is testament both to the successful hosting of previous events and our focus on improving facilities," said Sir Richard Leese, leader of the city council.
Lesley Tomlinson, chief executive of Manchester Central, described the securing of the contract as "marvellous news" and added that political conferences bring "huge benefits" to a city and the surrounding region.
The news follows the announcement that Liverpool venues will also benefit from the staging of the Labour party annual conference, when it comes to the Echo Arena and Convention Centre in 2011.